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15 May 2014

Denmark: Impact of ectopic pregnancy for reproductive prognosis in next generation

From Acta Obstetricia Gynecologica Scandavica.

The authors note that the impact of an ectopic pregnancy in the next generation is unknown. Their aim was to compare reproductive outcomes in daughters of women with and without ectopic pregnancy.

Designed as a historical prospective controlled cohort study with data collected in four Danish registries from 1977-2009, women with ectopic pregnancy during 1977-1982 were age-matched to women without ectopic pregnancy. Daughters of these two cohorts were followed until 2009.

The authors compared 5126 daughters of women with ectopic pregnancy with 19 928 daughters of women without ectopic pregnancy. The daughters of women with ectopic pregnancy had a 1.5-fold (95% confidence interval 1.2-1.9) increased risk of ectopic pregnancy, while for deliveries this was 1.0 (1.0-1.1), for miscarriages 1.1 (1.0-1.2), and for induced abortions 1.3 (1.2-1.4). Daughters of mothers with ectopic pregnancy have a 50% higher risk of ectopic pregnancy than daughters of women without an ectopic pregnancy, but a normal delivery rate.

Impact of ectopic pregnancy for reproductive prognosis in next generation. Kårhus LL, Egerup P, Skovlund CW, Lidegaard Ø. Acta Obstetricia Gynecologica Scandavica. 2014 Apr;93(4):416-9. doi: 10.1111/aogs.12332. Epub 2014 Feb 19.

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