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23 September 2011

China: Chromosomal abnormalities in patients with recurrent spontaneous abortions

This study aimed to investigate the ratio and types of chromosomal abnormalities in patients with recurrent spontaneous abortions (RSAs). From the Journal of Reproductive Medicine.

In this study, cytogenetic results of 734 patients with RSA, 360 men and 374 women, were referred to Norman Bethune Medicine College, Jilin University, Changchun, China, from May 2004 to December 2009. Among these 734 patients, 172 were couples. Gbanded cytogenetic analysis was performed based on our standard laboratory protocols, and results were given based on International System for Human Cytogenetic Nomenclature 2005 and 2009.

Of the total 734 patients, 22 patients were found to have abnormal karyotypes, which were believed to cause RSA. Eight of them were men (1.09%) and 14 were women (1.91%). The chromosomal abnormalities detected include reciprocal translocation (2.45%), dicentric abnormality (0.14%), Robertsonian translocation (0.27%), and inversion (0.14%).

The authors concluded that chromosomal abnormality is an important cause of RSA. It is very important to provide chromosomal analysis service for patients with RSA, and it should be considered as a standard medical care.

Center for Reproductive Medicine of the First Hospital, Jilin University, Changchun, People’s Republic of China.

Chromosomal abnormalities in patients with recurrent spontaneous abortions in northeast China. Zhang Z, Gao H, Li S, Hong M, Liu R. Journal of Reproductive Medicine. 2011 Jul-Aug;56(7-8):321-4.

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